Toshio Takagi Selected Research

Molecular Targeted Therapy

1/2022	Changes in Real-World Outcomes in Patients with Metastatic Renal Cell Carcinoma from the Molecular-Targeted Therapy Era to the Immune Checkpoint Inhibitor Era.
4/2021	Assessing improvements in metastatic renal cell carcinoma systemic treatments from the pre-cytokine to the immune checkpoint inhibitor eras: a retrospective analysis of real-world data.
1/2021	Efficacy of nivolumab versus molecular-targeted therapy as second-line therapy for metastatic renal cell carcinoma: Real-world data from two Japanese institutions.
5/2020	Efficacy of Axitinib After Nivolumab Failure in Metastatic Renal Cell Carcinoma.
6/2018	Efficacy and safety of third-line molecular-targeted therapy in metastatic renal cell carcinoma resistant to first-line vascular endothelial growth factor receptor tyrosine kinase inhibitor and second-line therapy.
8/2017	Limited benefit of targeted molecular therapy for inferior vena cava thrombus associated with renal cell carcinoma.
3/2017	Evaluation of tumor burden after sequential molecular-targeted therapy in patients with metastatic renal cell carcinoma.
1/2017	Time to progression after first-line tyrosine kinase inhibitor predicts survival in patients with metastatic renal cell carcinoma receiving second-line molecular-targeted therapy.
1/2017	Effect of Systemic Inflammation on Survival in Patients With Metastatic Renal Cell Carcinoma Receiving Second-line Molecular-targeted Therapy.
4/2013	Comparison of survival rates in patients with metastatic renal cell carcinoma according to treatment era including cytokine and targeted therapy.

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Toshio Takagi Research Topics

Disease

100	Renal Cell Carcinoma (Grawitz Tumor) 10/2022 - 05/2011
62	Neoplasms (Cancer) 10/2022 - 01/2008
15	Chronic Kidney Failure (Chronic Renal Failure) 07/2022 - 05/2011
15	Carcinoma (Carcinomatosis) 01/2022 - 05/2014
10	Neoplasm Metastasis (Metastasis) 01/2022 - 09/2012
9	Disease Progression 07/2022 - 01/2017
7	False Aneurysm (Pseudoaneurysm) 09/2020 - 09/2014
7	Ischemia 01/2020 - 09/2014
6	Infections 07/2022 - 03/2020
6	Acute Kidney Injury (Acute Renal Failure) 11/2021 - 09/2012
6	Chronic Renal Insufficiency 11/2017 - 06/2011
5	COVID-19 07/2022 - 01/2021
5	Thrombosis (Thrombus) 01/2022 - 07/2016
5	Margins of Excision 12/2021 - 01/2018
4	Urinary Bladder Neoplasms (Bladder Cancer) 07/2022 - 04/2016
4	Sarcopenia 04/2021 - 10/2016
4	Solitary Kidney 06/2020 - 02/2014
4	Pelvic Neoplasms 01/2020 - 05/2014
4	Hypothermia 01/2016 - 09/2014
3	Hemorrhage 01/2022 - 07/2015
3	Proteinuria 01/2022 - 11/2017
3	Kidney Neoplasms (Kidney Cancer) 02/2017 - 02/2014
2	Diarrhea 01/2021 - 01/2019
2	Hypertension (High Blood Pressure) 01/2021 - 01/2016
2	Prostatic Neoplasms (Prostate Cancer) 08/2020 - 11/2017
2	Anemia 05/2020 - 08/2019
2	Inflammation (Inflammations) 03/2018 - 01/2017
2	Renal Insufficiency (Renal Failure) 07/2015 - 09/2012
2	Hypertrophy 06/2015 - 12/2014
1	Hemolysis 12/2022
1	Autosomal Dominant Polycystic Kidney (ADPKD) 07/2022
1	Arthralgia (Joint Pain) 07/2022
1	Pneumonia (Pneumonitis) 07/2022
1	Fever (Fevers) 07/2022
1	Heart Diseases (Heart Disease) 05/2022
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 05/2022
1	Glomerulonephritis 01/2022
1	Pulmonary Embolism 01/2022
1	Circulating Neoplastic Cells 01/2022
1	Hematoma 01/2022
1	Frailty 01/2022

Drug/Important Bio-Agent (IBA)

27	NivolumabIBA 10/2022 - 07/2017
17	Immune Checkpoint InhibitorsIBA 06/2022 - 07/2017
12	Tyrosine Kinase InhibitorsIBA 01/2022 - 01/2016
10	IpilimumabIBA 10/2022 - 01/2021
9	Sunitinib (Sutent)FDA Link 01/2021 - 03/2014
8	C-Reactive ProteinIBA 05/2022 - 01/2017
5	Axitinib (AG 013736)IBA 05/2020 - 03/2017
4	Biomarkers (Surrogate Marker)IBA 05/2022 - 01/2016
4	pembrolizumabIBA 12/2021 - 01/2020
4	CytokinesIBA 04/2021 - 04/2013
3	CreatinineIBA 07/2022 - 01/2022
3	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2016
3	Sorafenib (BAY 43-9006)FDA Link 06/2021 - 05/2011
2	Everolimus FDA Link 07/2022 - 01/2021
2	Hemoglobins (Hemoglobin)IBA 01/2022 - 01/2022
2	Hormones (Hormone)IBA 12/2021 - 08/2020
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2021 - 03/2020
2	AlbuminsIBA 09/2021 - 03/2021
2	Alanine Transaminase (SGPT)IBA 01/2020 - 10/2017
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2020 - 10/2017
2	Microphthalmia-Associated Transcription FactorIBA 08/2019 - 03/2019
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 06/2019 - 06/2018
1	Complement System Proteins (Complement)IBA 12/2022
1	Therapeutic UsesIBA 10/2022
1	Monoclonal AntibodiesIBA 07/2022
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 07/2022
1	Heparin (Liquaemin)FDA LinkGeneric 07/2022
1	casirivimab and imdevimab drug combinationIBA 07/2022
1	cabozantinibIBA 06/2022
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 05/2022
1	Dalteparin (Dalteparin Sodium)FDA Link 03/2022
1	Dexamethasone (Maxidex)FDA LinkGeneric 03/2022
1	VaccinesIBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2022
1	Immunoglobulins (Immunoglobulin)IBA 01/2022
1	BNT162 VaccineIBA 01/2022
1	CalciumIBA 01/2022
1	mRNA VaccinesIBA 01/2022

Therapy/Procedure

70	Nephrectomy 10/2022 - 06/2011
56	Therapeutics 10/2022 - 01/2008
14	Renal Dialysis (Hemodialysis) 07/2022 - 05/2011
10	Molecular Targeted Therapy 01/2022 - 04/2013
10	Warm Ischemia 12/2021 - 09/2014
8	Kidney Transplantation 07/2022 - 06/2010
7	Nephroureterectomy 01/2022 - 05/2014
6	Lymph Node Excision (Lymph Node Dissection) 04/2021 - 05/2014
5	Cystectomy 07/2022 - 04/2016
5	Operative Time 01/2022 - 07/2016
4	Immunotherapy 10/2022 - 04/2021
4	Thrombectomy 01/2022 - 11/2013
4	Eye Enucleation (Enucleation, Eye) 12/2021 - 01/2019
4	Length of Stay 12/2021 - 08/2014
3	Anesthesia 01/2022 - 01/2008
3	Drug Therapy (Chemotherapy) 12/2021 - 07/2015
3	Metastasectomy 01/2021 - 01/2020
2	Transplantation 07/2022 - 01/2019
2	Laparotomy 01/2022 - 03/2020
2	Aftercare (After-Treatment) 01/2020 - 01/2016
2	Adrenalectomy 01/2020 - 01/2019